About 1 result found for searched term "MG-277" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21153 | MG-277 | PROTAC |
| MG-277 is a molecular gel degrader that efficiently induces degradation of the translation termination factor GSPT1 based on Cereblon E3 ligands with a DC50 of 1.3 nM. MG-277 inhibits tumor cell growth in a non-p53 manner with an IC50 of 3.5 nM and 3.4 nM for RS4;11 cells and p53 mutant RS4;11/IRMI-2 cells, respectively. MG-277 exhibited potent anticancer activity. | ||
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